{"id":3423,"date":"2022-02-15T17:17:15","date_gmt":"2022-02-15T16:17:15","guid":{"rendered":"https:\/\/www.simcardiotest.eu\/wordpress\/?p=3423"},"modified":"2022-02-22T13:54:49","modified_gmt":"2022-02-22T12:54:49","slug":"verification-validation-of-in-silico-models-a-european-effort","status":"publish","type":"post","link":"https:\/\/www.simcardiotest.eu\/wordpress\/verification-validation-of-in-silico-models-a-european-effort\/","title":{"rendered":"Verification &#038; validation of in-silico models, a european effort"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3423\" class=\"elementor elementor-3423\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6bddba15 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6bddba15\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7ffdda3d\" data-id=\"7ffdda3d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-32e1b83d elementor-widget elementor-widget-text-editor\" data-id=\"32e1b83d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a1d5c0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a1d5c0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f05f38b\" data-id=\"f05f38b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-69c3b0f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"69c3b0f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3e8593e\" data-id=\"3e8593e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-834de32 elementor-widget elementor-widget-text-editor\" data-id=\"834de32\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span class=\"JsGRdQ\"><a href=\"https:\/\/www.youtube.com\/watch?v=a2KDDz4yEDM&amp;t=2s\">SimCardioTest<\/a> takes the mature field of cardiac simulations and brings it further through a web-based platform to perform standardised in-silico trials for testing the efficacy and safety of drugs and devices in 3 concrete use cases. <\/span><span class=\"JsGRdQ\">The verification and uncertainty quant-ification, to abide by the standards, will allow to quantify discretisation error (in time and space), numerical solver error. <\/span><span class=\"JsGRdQ\">Uncertainty in model predictions will be compared to actual measurement. And to extend the verification, validation will be implemented according to the ASME V&amp;V 40 standards including risk eval-uation as well as certification support for in-silico trials.<\/span><\/p><p><span class=\"JsGRdQ\">To further discuss verification &amp; validation processes for in-silico models,\u00a0\u00a0 <strong>SimCardioTest organised a workshop on 8 February 2022 with the other EU funded projects<\/strong>: <a href=\"http:\/\/www.siminsitu.eu\">SimInSitu<\/a>, <a href=\"https:\/\/www.simcor-h2020.eu\">SIMCor<\/a>, <a href=\"https:\/\/insilico.world\/\">InSilicoWorld<\/a> &amp; <a href=\"https:\/\/www.eu-stands4pm.eu\/\">EU-stands4PM. <\/a><br \/><\/span><\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3435 aligncenter\" src=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/logos2-300x169.jpg\" alt=\"\" width=\"300\" height=\"169\" srcset=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/logos2-300x169.jpg 300w, https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/logos2-1024x576.jpg 1024w, https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/logos2-768x432.jpg 768w, https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/logos2.jpg 1280w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-50eaae4\" data-id=\"50eaae4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9dc4695 elementor-widget elementor-widget-text-editor\" data-id=\"9dc4695\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><i>\u00a0<\/i><\/p><p><i>Hundred of participants attended the workshop to listen: \u00a0<\/i><b> <\/b><\/p><ul><li><i>Maxime Sermesant, from Inria, Coordinator of SimCardiotest, opened the workshop with a <\/i>Welcome note &amp; <a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/SimCardioTest_presentation_Sermesant_WKVV-.pdf\">presentation of the SimCardioTest project<\/a>.<\/li><li>Romano Setzu, from\u00a0 Microport, on <a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/SimCardioTest_-MRI-Modeling_Setzu_SimCardioTest_WS_2022-08-02.pdf\"><strong>Verification &amp; Validation of Modeling for MRI conditional safety<\/strong><\/a><strong>.<\/strong><i><br \/><br \/>A session, dedicated to the Coordinators of the different european projects, who\u00a0 presented their approaches in V&amp;V. , was moderated by Liesbet Geris, Director of the <a href=\"https:\/\/www.vph-institute.org\/\">VPHi<\/a>.<\/i><\/li><li><a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/InSilicoWorld_Good-Simulation-Practice-position-paper_Viceconti_SimCardioTest_WS_2022-08-02.pdf\"><b>InSilicoWorld<\/b><b> and the Good Simulation Practice position <\/b><b>paper<\/b><\/a><b>, <\/b>Marco Viceconti, Universit\u00e0 di Bologna<\/li><li><a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/InSilicoWorld_Good-Simulation-Practice-position-paper_Viceconti_SimCardioTest_WS_2022-08-02.pdf\"><b>SIMCor<\/b><b>: Validation Strategy for in-silico <\/b><b>testing<\/b><b> of <\/b><b>medical<\/b> <b>devices<\/b> <b>based<\/b><b> on virtual <\/b><b>cohorts<\/b><\/a><b>, <\/b>Jan Br\u00fcning, Charit\u00e9, Institute of Computer-assisted Cardiovascular Medicine<\/li><li><a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/SimInSitu-Challenges-Opportunities-Implementing-A-Tiered-Validation-Approach_Gotzen_SimCardioTest_WS_2022-08-02.pdf\"><b>SimInSitu<\/b><b> &#8211; Challenges &amp; <\/b><b>Opportunities<\/b> <b>Implementing<\/b><b> A <\/b><b>Tiered<\/b><b> Validation <\/b><b>Approach<\/b><b>, <\/b><\/a>Nils G\u00f6tzen, 4realsim<\/li><li><a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/EUStand4PM_ISO-Technical-Specification-for-computational-modellingapproaches_Kirshner_SimCardioTest_WS_2022-08-02.pdf\"><b>EU-Stands4pm, ISO-<\/b><b>Technical<\/b> <b>Specification<\/b><b> for <\/b><b>computational<\/b> <b>modelling<\/b> <b>approaches<\/b><\/a><b>, <\/b>Marc Kirshner, Forschungszentrum J\u00fclich GmbH<\/li><li><a href=\"https:\/\/www.simcardiotest.eu\/wordpress\/wp-content\/uploads\/2022\/02\/SimCardioTest-Golebiewski-Feb2022_final.pdf\"><b>Standards for in-silico modeling in <\/b><b>health<\/b> <b>research<\/b><b> and <\/b><b>medicine<\/b><\/a>, Martin Golebiewski, HITS gGmbH &#8211; Heidelberg Institute for Theoretical Studies<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cfd6cc9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cfd6cc9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7ce67ba\" data-id=\"7ce67ba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>SimCardioTest takes the mature field of cardiac simulations and brings it further through a web-based platform to perform standardised in-silico trials for testing the efficacy and safety of drugs and devices in 3 concrete use cases. The verification and uncertainty quant-ification, to abide by the standards, will allow to quantify discretisation error (in time and [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-3423","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts\/3423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/comments?post=3423"}],"version-history":[{"count":31,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts\/3423\/revisions"}],"predecessor-version":[{"id":3465,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts\/3423\/revisions\/3465"}],"wp:attachment":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/media?parent=3423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/categories?post=3423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/tags?post=3423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}