{"id":4303,"date":"2023-07-05T14:15:54","date_gmt":"2023-07-05T13:15:54","guid":{"rendered":"https:\/\/www.simcardiotest.eu\/wordpress\/?p=4303"},"modified":"2023-07-05T14:24:13","modified_gmt":"2023-07-05T13:24:13","slug":"pre-post-doctoral-position-at-upv","status":"publish","type":"post","link":"https:\/\/www.simcardiotest.eu\/wordpress\/pre-post-doctoral-position-at-upv\/","title":{"rendered":"Research position at UPV, Spain"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

The Cardiac Modeling Group belongs to the Electronics Engineering Department of the <\/span>Polytechnical University of Valencia (UPV), Spain. The group is integrated by 5 faculty members\u00a0<\/span>and a variable number of post-doctoral and PhD students. We seek two highly motivated\u00a0<\/strong><\/span>candidate<\/span> (predoctoral or postdoctoral) to develop computational multiscale personalized <\/span>models of the electrical activity of the heart to enable the<\/span> in silico<\/span> testing of drug efficacy and <\/span><\/strong>safety under healthy and pathological conditions.<\/strong>\u00a0<\/span><\/span><\/p>

The candidates will be contracted for three <\/span>years and working in the frame of the EU funded research project: <\/span><\/span>\u201cSimulation of Cardiac Devices & Drugs for in-silico Testing and Certification\u201d (SimCardioTest), <\/span>Call H2020-SC1-DTH-2018-2020, Research and Innovation Action (Topic SC1-DTH-06-2020).<\/span><\/span>
The candidate will be fully integrated in the group as active members.<\/span><\/span><\/p>

The group has an ample experience in modeling and simulating the electrical activity of the <\/span>heart. Throughout our cardiac simulation work, we have developed and analyzed cardiac action <\/span>potential (AP) models of different tissues (atrium, ventricle, and Purkinje) and different animal <\/span>species (dog, rabbit, guinea pig, and human) under normal and under several pathological <\/span>conditions, such as ischemia, heart failure, atrial fibrillation, and mutations. The group also has a <\/span>valuable experience in modeling the effects of drugs on different ionic channels. Moreover, we have <\/span>developed computational tools for the simulation of the electrophysiological activity of a variety of <\/span>tissue\u00a0 structures (unicellular, one-dimensional, bi-dimensional and tri-dimensional).<\/span><\/span><\/p>

<\/span>
ROLE SUMMARY:<\/span><\/span><\/strong><\/span>
The candidate will develop cellular to 3D cardiac personalized models to simulate the effects of <\/span>drugs on the electrical activity of the heart. Methods of image processing and mathematical <\/span>modeling will be used to achieve the objectives. The candidate will receive data from our <\/span>collaborators from the clinical and pharmaceutical field to build realistic and personalized models,\u00a0<\/span>as well as population of models considering variability and uncertainty. The effects of drugs under\u00a0\u00a0<\/span>several pathological conditions will be analyzed in silico.<\/span><\/span><\/span>

<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

CANDIDATE RESPONSIBILITIES:<\/span><\/strong>
1. Development of drug ion channel interaction models and assess drug effects at the cellular <\/span>level in healthy and pathological virtual populations.<\/span><\/p>

2. Development of multiscale personalized models, as well as populations of models, where <\/span>variability will be considered. Differences in gender and age will also be considered.<\/span><\/p>

3. In silico assessment of safety and efficacy of drugs in validated, anatomically-based multi-<\/span>scale predictive cardiac models for healthy and patient-specific disease conditions.<\/span><\/p>

4. Identification of selective and specific biomarkers to improve prediction of drug efficacy and <\/span>safety.<\/span><\/p>

5. Uncertainty quantification and propagation<\/span><\/p>

CONTRACT DETAILS:<\/span><\/span><\/strong>
Applications:<\/span> July 2023<\/span><\/span>
Initial date:<\/span> September-October 2023<\/span><\/span>
Duration:<\/span> 1.5 years at full and exclusive dedication.<\/span><\/span><\/span>
<\/span><\/p>

QUALIFICATIONS:<\/span><\/span><\/strong>
\u2022<\/span> PhD in in Engineering, Mathematics or Physics will be highly valued.<\/span><\/span>
\u2022<\/span> Master<\/span> Degree<\/span> in<\/span> Biomedical<\/span> Engineering,<\/span> Applied<\/span> Mathematics,<\/span> Physics,<\/span> other<\/span>
Engineering degrees or related discipline with strong numerical components focusing on<\/span>
mathematical modeling, simulation, and image processing.<\/span><\/span>
\u2022<\/span> Training and\/or experience in mechanistic modeling of electrophysiological systems is<\/span>
preferred.<\/span><\/span>
\u2022<\/span> Understanding of ordinary and partial differential equations and how these can be<\/span>
applied in the development of complex models of electrophysiological models.<\/span><\/span>
\u2022<\/span> In-depth, hands-on knowledge of modeling and simulation software (MATLAB, C\/C++,<\/span>
Fortran).<\/span><\/span>
\u2022<\/span> Keen interest in learning new computational skills.<\/span><\/span>
\u2022<\/span> Self-directed with ability to work independently.<\/span><\/span>
\u2022<\/span> Excellent communication and writing skills in English.<\/span><\/span>
\u2022<\/span> Keen interest in living in the sunny Valencia.<\/span><\/span><\/span>
<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t

CONTACT:<\/span><\/span><\/strong>
For additional information about the position and details on how to apply, please contact <\/span>Professor: Beatriz Trenor (<\/span><\/strong><\/span>btrenor @ eln.upv.es<\/span><\/span>) by the end of July 2023<\/span><\/span><\/strong><\/p>

Research_Position_UPV_June2023<\/a><\/span><\/span><\/span><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

The Cardiac Modeling Group belongs to the Electronics Engineering Department of the Polytechnical University of Valencia (UPV), Spain. The group is integrated by 5 faculty members and a variable number of post-doctoral and PhD students. We seek two highly motivated candidate (predoctoral or postdoctoral) to develop computational multiscale personalized models of the electrical activity of the heart […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-4303","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts\/4303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/comments?post=4303"}],"version-history":[{"count":5,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts\/4303\/revisions"}],"predecessor-version":[{"id":4309,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/posts\/4303\/revisions\/4309"}],"wp:attachment":[{"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/media?parent=4303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/categories?post=4303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.simcardiotest.eu\/wordpress\/wp-json\/wp\/v2\/tags?post=4303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}