9 Workpackages
Model Standardization & Interoperability
Project leader Simula Research laboratory AS (SRL)
The aim is the development of a cloud-based in-silico clinical trial interface that will serve as the interconnection layer between the models & data, in order to perform the test cases.
- Start date
Jan 2021
- End date
Dec 2023
Use Case 1 – Pacing Leads & Catheters
Project leader Université de Bordeaux (UBx)
This WP will set up case-studies for in-silico simulation of cathetersation, implantation and pacing of cardiac devices.
- Start date
Jan 2021
- End date
Dec 2022
Use Case 2 – Left Atrial Appendage Occluder
Project leader Universitat Pompeu Fabra (UPF)
This WP will generate in-silico personalised haemodynamic indices of left atrial geometries, to identify the risk of thrombus formation in atrial fibrillation patients.
- Start date
Jan 2021
- End date
Dec 2022
Use Case 3 – Drug Efficacy & Cardiotoxicity
Project leader Universitat Politècnica de València (UPV)
The main objective is to set up cases on the use of in-silico models for the simulation of drug efficacy safety and career toxicity.
- Start date
Jan 2021
- End date
Dec 2024
In-silico Trials & Data Science
Project leader Institut National de recherche en science et technologies du numérique (inria)
The WP aims to run in-silico trials for each of the selected use cases & will propose more advanced statistical analysis of the data generated by the in-silico trials
- Start date
Jan 2022
- End date
Dec 2024
Verification, Validation, Uncertainty Quantification & Certification
Project leader MicroPort Sorin (MPC)
This WP will focus on formalizing and standardizing important aspects of computational modelling for in-silico trials
- Start date
Jan 2021
- End date
Dec 2024
Exploitation, Dissemination & Communication
Project leader The Virtual Physiological Human Institute for Integrative Biomedical Research (VPHi)
The objective is to disseminate results but also facilitate the positioning of the project outcomes for future market replication, commercial exploitation & training
- Start date
Jan 2021
- End date
Dec 2024
Project Coordination & Management
Project leader Institut National de recherche en science et technologies du numérique (inria)
The main objective is to carry out an effective technical, scientific, legal, financial and administrative coordination.
- Start date
Jan 2021
- End date
Dec 2024
Ethics requirements
Project leader Institut National de recherche en science et technologies du numérique (inria)
This WP will ensure the respect of the ethical conduct of research imposed by the European Commission, and compliance with the General Data Protection Regulation (GDPR).
- Start date
Jan 2021
- End date
Dec 2024
Timeline
2021
Standardization & calibration
Use case standardisation & implementation: Standardise models, Aquire experimental data, Calibrate on training set
2022
Verification, validation & uncertainty codification
Standardization & calibration and verification, validation & uncertainty codification
2023
In-silico trials
Hybrid cloud orchestration, evaluation on testing set: trial on virtual population for evaluation & biomarker discovery
2024
Certification support
Generate report, qualitfy impact, influence policy for communication, dissemination and exploitation