SimCardioTest takes the mature field of cardiac simulations and brings it further through a web-based platform to perform standardised in-silico trials for testing the efficacy and safety of drugs and devices in 3 concrete use cases. The verification and uncertainty quant-ification, to abide by the standards, will allow to quantify discretisation error (in time and space), numerical solver error. Uncertainty in model predictions will be compared to actual measurement. And to extend the verification, validation will be implemented according to the ASME V&V 40 standards including risk eval-uation as well as certification support for in-silico trials.
To further discuss verification & validation processes for in-silico models, SimCardiotest organises a workshop on 8 February 2022 at 2pm with other EU funded projects: SimInSitu, SIMCor, InSilicoWorld & EU-stands4PM.
Agenda and links to access to the workshop
14h00 – SimCardioTest Welcome note & Presentation, Maxime Sermesant, Inria
14h20 – Keynote Lecture on Verification & Validation of Modeling for MRI conditional safety, Romano Setzu, Microport
15h00 – Verification & Validation processes across EU H2020 projects – Moderator Liesbet Geris, VPHi
- InSilicoWorld and the Good Simulation Practice position paper, Marco Viceconti, Università di Bologna
- SIMCor: Validation Strategy for in-silico testing of medical devices based on virtual cohorts, Jan Brüning, Charité, Institute of Computer-assisted Cardiovascular Medicine
- SimInSitu – Challenges & Opportunities Implementing A Tiered Validation Approach, Nils Götzen, 4realsim
- EU-Stands4pm, ISO-Technical Specification for computational modelling approaches, Marc Kirshner, Forschungszentrum Jülich GmbH
- Standards for in-silico modeling in health research and medicine, Martin Golebiewski, HITS gGmbH – Heidelberg Institute for Theoretical Studies
Discussion – 16h30: end of the workshop