access to our work
An overview of the progress towards the objectives of SimCardioTest, including milestones and deliverables are available here.
WP1 – Model Standardisation & Interoperability
WP2 – Use Case 1 – Pacing Leads & Catheters
WP3 – Use Case 2 – Left Atrial Appendage Occluder
WP4 – Drugs, Efficacy & Cardiotoxicity
WP5 – In-silico Trials & Data Science
WP6 – Verification, Validation, Uncertainty Quantification & Certification
WP7 – Exploitation, Dissemination & Communication
WP8 – Project Coordination & Management
WP9 – Ethics
Deliverables
- D1.1 Modelling & personalisation survey
June 2021 - Survey response on the different pipelines that will be implemented in the Use Cases
D1.1-Modeling and personalisation survey - D1.2 - Global standardisation
June 2022 - Specification document on the chosen formalism for standardized modelling and personalization.
D1.2 - Global standardisation. - D1.3 - Cloud-based platform for pacing device simulation
December 2022 - Video recording of Use Case 1 cloud-based platform demo
D1.3 Cloud-based platform for pacing device simulation - D1.4 - Cloud-based platform for LAAO simulation
December 2022 - Video recording of Use Case 2 cloud-based platform demo
D1.4 Cloud-based platform for LAAO simulation - D1.5 - Cloud-based platform for drugs simulation
December 2022 - Video recording of Use Case 3 cloud-based platform demo
D1.5 Cloud-based platform for drugs simulation
- D2.1 Report on the standardised models for interventional devices (Use Case 1)
December 2021 - UC1 computational pipelines and input-output standardized formats
D2.1 Report on standardised model for leads and catheters - D2.2. Demonstration of several catheters simulated and real ones
June 2022 - Examples of navigation of a lead numerical model inside a virtual anatomy, and the same scenario in a benchmark where the real commercial lead is navigated through a 3D printed anatomical phantom.
D2.2. Demonstration of several catheters simulated and real ones - D2.4 - Evaluation of fatigue models against experimental data
March 2023 - Report on the 3D model and physical phantom that were developed to study the implantation of a cardiac pacing lead.
Confidential
- D3.1 Report on the standardised models for LAAO devices (Use Case 2)
December 2021 - Workflow and input-output standardised formats for LAAO device modelling (Use Case 2)
D3.1 Report on standardised model for LAAO devices - D3.2 Fluid simulations with optimised boundary conditions.
June 2022 - Sensitivity analyses of relevant parameters for realistic fluid simulations.
D3.2_Fluid simulations with optimised boundary conditions - D3.3 - Demonstration of interactive tool for LAAO device setting selection
December 2022 - Video recording of Use Case 2 cloud-based platform demo
Confidential - D3.4 - Database of fluid simulations in virtual population
December 2022 - Database structure and workflow for virtual population development
D3.4 Database of fluid simulations in virtual population - D3.5 - LAAO device implantation simulations in virtual population
December 2022
Confidential
- D4.1 Report on the standardised models for drugs (Use Case 3)
December 2021 - UC3 workflow and input-output standardised formats
D4.1 Report on standardised model for drugs - D4.2 Software API for pharmacokinetics
June 2022 - This document describes API specification
D4.2 Software API for pharmacokinetics - D4.3 - Database of virtual human cardiac models with drug interaction
January 2023 - Online database of human ventricular tissue with ability to simulate drug effects
D4.3-Database of virtual human cardiac models with drug interaction - D4.5 - Demonstrator of simulation of drug effects in cellular and 3D models
January 2023 - Video of simulations performed in Use Case 3
D4.5-Demonstrator of simulation of drug effects in cellular and 3D models
- D5.1 Report on the in-silico trial of pacing leads & catheters
December 2023 - In silico trial that determines the proportion of population that undergoes loss-of-capture due to fibrosis after implantation of a bradycardia pacemaker in the right ventricle
D5.1_UC1_Report on In Silico Trial of pacing leads & catheters - D5.2 Report on the in-silico trial of the virtual population's fluid simulation database.
December 2023
Confidential - D5.3 Report on the in-silico trial of drug efficacy & cardiotoxicity
December 2023 - In-silico trial tool to determine drug concentrations assuring TdP-related safety in different groups of patients. Example with Dofetilide
D5.3_UC3_Report on the in-silico trial of drug efficacy & cardiotoxicity
- D6.1 Verification & uncertainty quantification for the 3 use cases
June 2023 - Implementation of Verification on a selection of Models developed for the Use Cases of WP2-4
Upcoming - D6.2 Validation of the model predictions for the use cases
June 2023 - Implementation of Validation on a selection of Models developed for the Use Cases of WP2-4
Upcoming
- D7.1 Dissemination and Communication strategy plan
February 2021 - Report on the communication and dissemination activities strategy for the project.
D7.1 Communication-Dissemination Strategy plan Revised - D7.2 Website and online presence
May 2021 - Report on activities conducted for Project website and social media accounts online.
D7.2website - D7.3 - Preliminary Exploitation strategy and market assessment
December 2022 - Preliminary description of exploitable outputs and their exploitation strategy
Confidential - D7.4 - Communication toolkits for physicians & patient organisations
February 2024
D7.4_Communication_toolkits_for_physicians_and_patient_organisations
- D8.1 SimCardiotest WP8 Online space
January 2021 - Report on the necessary tools for project management
Confidential - D8.2 Project Quality Plan
March 2021 - Document to guide the team and the stakeholders on the quality requirements, standards and the quality assurance mechanisms of the project.
Confidential - D8.3 Intellectual Property management plan
June 2021 - Report to detail the IP management
D8.3 intellectual property Management plan - D8.4 -AB recommendation & SG request
June 2022 - Report on the first feedback from the Advisory Board and request from the stakeholder group
Confidential - D8.5 - Intermediate Advisory Board recommendations and stakeholder group’s request
June 2023
D8.5_intermediate report AB recommendations & SG request - D8.7 Data management plan
June 2021 - Report to detail the data management
D8.7 Data_Management
- D9.1 POPD - Requirement No. 2
June 2021 - Document on responses to EC ethics requirements
Confidential
Milestones
- D7.1 Dissemination and Communication strategy plan
February 2021 - Report on the communication and dissemination activities strategy for the project.
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